Introduction to the hottest film coating technolog

Introduction to film coating technology (IV)

<1. With the continuous development of transportation in China, the production cost of film coating technology

? In the early 1950s, the western medicine film coating tablet technology, which was first used in the production of pharmaceutical preparations industry, was born in the United States. After more than half a century of development, this technology has been widely used in the production field of pharmaceutical preparations industry in the world. Compared with western medicine tablets, the application of film coating technology in Chinese patent medicine tablets is very different, and it was introduced into China later. The film coating technology was formally applied to the production of Chinese patent medicine tablets in China only in the late 1990s, which was a short time. At the initial stage of the promotion and use of film coating technology in the production of Chinese patent medicine industry, because the film coating powder or various raw and auxiliary materials and coating machinery and equipment required for the preparation and production of film coating powder have to be imported from abroad, the price is expensive, the production cost of film coating technology is high, and the price of Chinese patent medicine film coating tablets remains high, which restricts the process of the promotion and application of this technology. In recent years, the materials required for the film coating technology have basically been localized, and the price is low. It has gradually approached the production cost of traditional Chinese patent medicine sugar coated tablets, and the production technology is also very mature, entering the golden period of promotion and application

 from the current overall situation, the production cost of film coating technology in Chinese patent medicine tablets, if only from the price of coating powder or related raw and auxiliary materials, there is still a certain gap compared with sugar coated tablets. If we look at the whole process of the overall technology, the production cost of film coating technology applied to Chinese patent medicine tablets is basically close to, or even equal to, sugar coated tablets, and there is still a large room for production cost reduction. In addition, the economic and social benefits of Chinese patent medicine film coating technology itself are far more than sugar coated tablets. This is also the main reason for the rapid development of the application of film coating technology in the production of Chinese patent medicine industrial tablets and the substantial increase in the market sales of Chinese patent medicine film coated tablets in recent years. The timely introduction of film coating technology and the use of this advanced technology in production should attract the great attention of production enterprises

Second, film coating is a complete set of comprehensive technology. Unlike the production technology of sugar coated tablets, the process production of Chinese patent medicine film coated tablets is a complete comprehensive technology, and all links are indispensable. For example, the film coating technology is quite different from the sugar coated tablet production technology in terms of core hardness, surface finish, auxiliary material selection, process operation, etc. If the production method or technology of sugar coated tablets is applied, and 7. The tensile testing machine is used to lubricate the film coated tablets of Chinese patent medicines, the expected effect is often not achieved. Even different varieties of Chinese patent medicines cannot use the same film coating powder or coating method because of the different surface properties of the cores. Many pharmaceutical manufacturers have introduced film coating technology to produce Chinese patent medicine coated tablets. The results are unsatisfactory and the purpose cannot be achieved. This is the crux of the problem

 traditional excipients or production methods are used to process the core of Chinese patent medicine for the production of film coated tablets, which often leads to a series of problems, such as the disintegration time limit of the tablets does not meet the requirements, the hardness of the core is poor, one-sided roughness and so on, resulting in the poor quality of Chinese patent medicine film coated tablets. To solve these problems, the most effective way is to start with the selection of new auxiliary materials, adjust the feeding formula, and modify the production process and relevant operating procedures accordingly. In particular, the selection and use of new excipients is very important, which has developed rapidly in Europe and the United States, and thus derived a new industry - (pharmaceutical) fine excipients. While actively introducing film coating technology, Chinese patent medicine preparation industry enterprises should also consider from a higher level or perspective, which is also an opportunity to scientifically adjust and improve their own production technology level, killing two birds with one stone, so as to improve the overall management level

 third, the production technology of thin film coating powder

 sugar coated tablets is reasonably selected, which is applicable to almost all Chinese patent medicine tablets and Western medicine tablets. The technology of film coated tablets is different. Due to the complex composition of Chinese patent medicine, the film coated powder varies greatly due to the different materials or formulas used. The physical properties and surface properties of the chip core are different, and the selectivity of the film coated powder is strong. For example, a film coating powder and its technical parameters are often only suitable for one or several Chinese medicine tablets. It is very easy to find the corresponding film coating powder for the production of different varieties of Chinese patent medicine tablet cores after small-scale test. Generally speaking, the core surface of Chinese patent medicine must have a good affinity with the film coating powder in order to produce high-quality Chinese patent medicine film coating tablets, which is an important part of the introduction of this technology. The physical properties of different Chinese patent medicine tablet cores are different. The selection of matching film coating powder is the key factor for the film coating process of Chinese patent medicine, the success or failure of production and the quality of tablets

58. When introducing film coating technology, some Chinese patent medicine manufacturing enterprises often adopt the method of preparing film coating powder for their own use. This self-produced and self sold deployment method is the worst choice of Chinese patent medicine manufacturing enterprises under the condition that China has just introduced film coating technology from abroad a few years ago, and there is no professional film coating powder manufacturing enterprise in China or the price of imported film coating powder is very expensive, As a result, the production technology of film coating of Chinese patent medicine is unstable, the quality of tablets is poor, and the production process cannot be quantified, which is not conducive to the promotion of this technology

In recent years, a number of professional film coating enterprises have emerged in China, which have been able to produce various types of film coating powder for the production of film coated tablets of Chinese patent medicine; Film coating manufacturers can also set special film coating varieties that match the process technology according to the specific requirements or specific indicators of Chinese patent medicine tablet preparation enterprises, provide corresponding pre-sales and after-sales supporting services, and produce high-level and high-quality Chinese patent medicine film coating tablets. At present, the gap between the R & D and production technology of China's film coating powder production industry and the international advanced level is rapidly narrowing. The products are of high quality, many varieties and good performance, and can completely replace imported products. At the same time, the film coating powder produced in China is also supplied for export in large quantities. The R & D innovation and production and operation strength of China's film coated powder production enterprises have been greatly enhanced, which has injected new vitality into the promotion and application of film coated technology of Chinese patent medicine, reduced production costs, and improved the quality of Chinese patent medicine tablets, and also created good backup material guarantee conditions for Chinese patent medicine production enterprises to introduce advanced production technology of film coated tablets

 v. operation problems of film coating technology

 in the production of Chinese patent medicine tablets, the introduction of film coating technology or production process often leads to some problems, such as sticking tablets, orange peel film, pinholes, tablet color difference, spray, edge collapse, color spots, etc. Under the current production technology or equipment conditions, it is very easy to solve, and it is no longer a difficult problem of film coating technology. Especially in recent years, China's pharmaceutical preparation machinery industry has driven the rapid development of China's pharmaceutical preparation machinery industry and accelerated the process of localization through the introduction and digestion of international advanced technology. For example, at present, the performance and main technical parameters of the high-efficiency film coating pot produced in China have approached or even reached the international advanced level, but the sales price has shown a sharp decline, only 20% of the imported machinery of the same kind. The application of film coating technology in the production of Chinese patent medicine tablets is simpler and easier due to the popularity of domestic high-efficiency film coating machinery and equipment with good quality and low price. Chinese patent medicine manufacturers should be full of confidence in introducing film coating production technology. As long as we adjust the operation technology of high-efficiency film coating machinery and equipment, the Huafeng spandex polyurethane curing track bed project has completed the experimental technical indicators of the freight line and prepared the process procedures, we can easily quantify or numerically control the production technology of Chinese patent medicine film coated tablets, make the operation technology simple and easy to learn, and solve the technical problems in production, It provides a successful guarantee for the wide application of film coating technology of Chinese patent medicine